Acute Arthritis and Sudden Joint Pain in Multiple Joints

Acute arthritis is a term that refers to rapid or sudden onset of joint inflammation and pain. Acute arthritis that causes your joints to hurt suddenly can be caused by several processes, including autoimmune diseases. Autoimmune diseases occur when the body mistakenly attacks healthy cells and tissues, causing inflammation.

The main symptoms of acute arthritis include joint pain, joint warmth, tenderness, swelling, and stiffness causing decreased range of motion.

This article explains the causes and types of acute arthritis, and the risk factors that may lead to episodes of sudden joint pain. It presents information about how these conditions are diagnosed.

Types of Arthritis

An arthritis diagnosis is common, especially as people age and experience osteoarthritis. This condition tends to emerge over time, for example, with wear and tear to the joints.

Certain types of arthritis cause acute symptoms, rather than chronic symptoms over time. Here's a look at some types of acute arthritis that cause your joints to hurt suddenly.

Acute Inflammatory Arthritis 

Acute inflammatory arthritis refers to a group of diseases triggered by an overactive immune system that typically attacks several joints (and perhaps other systems in your body) at the same time.

Getting diagnosed and treated early is essential to preventing this type of arthritis from becoming a chronic condition. While exact incidence is unknown, it is less common than other types of arthritis, such as osteoarthritis.

Symptoms of acute inflammatory arthritis include:

• Joint pain and stiffness after periods of rest or inactivity, particularly in the morning, lasting about an hour
• Swelling, redness, and warmth in the affected joints

Septic Arthritis 

Septic arthritis refers to joint infection caused by bacteria, viruses, fungi, or parasites. Bacteria are the most common cause and most serious due to a highly destructive nature. Incidence varies in the United States, causing between two to 10 cases per 100,000 people.

Signs of septic arthritis include:

• Fever
• Feeling unwell or malaise
• Pain in the affected joint
• Warmth in the affected joint
• Swelling (effusion) in the affected joint
• Decreased range of motion in the affected joint

Gout

Gout is an extremely painful condition caused by a buildup of uric acid crystals in the joints. This buildup occurs when there is too much uric acid in your body, a condition known as hyperuricemia. More than 30% of people with gout also have hypertension (high blood pressure).

The body makes uric acid when it breaks down purines, which are found in your body and the foods you eat. When there is too much uric acid in the body, uric acid crystals (monosodium urate) can build up in joints, fluids, and tissues within the body.

Gout usually affects one joint at a time, most commonly the big toe joint. The incidence of gout among adults in the United States is 3.9%.

The symptoms of gout include:

• Pain, usually intense
• Swelling
• Redness
• Heat

Bacterial Arthritis 

Bacterial arthritis develops over hours or days. It is categorized as either gonococcal or nongonococcal. The main difference is that the gonococcal type is caused by the spread of the gonorrhea bacteria and nongonococcal infections are not.

Symptoms of gonococcal arthritis include:

• Fever
• Tendon inflammation
• Painless lesions (papules, pustules, or macules) on the arms and legs
• Single joint arthritis (monoarticular)
• Areas typically affected are the knees, ankles, and wrists.

Symptoms of nongonococcal arthritis include:

• Moderate to severe joint pain that worsens with movement
• Infected joints are swollen, red, and warm.
• Low-grade fever
• Areas affected are typically the knees, hips, wrists, ankles, or elbow joints.

Diagnosis

If acute arthritis is suspected, your healthcare provider will examine the area of concern and check for tenderness, swelling, redness, and other obvious signs of the disease. They will ask about your medical history, including any family history of arthritis, and questions about when your symptoms first started and how they’re affecting your everyday activities.

After the physical exam, your healthcare provider will order a blood panel and urine test to check for the markers of arthritis and rule out other conditions that may be contributing to or causing your symptoms.

Complete Blood Cell Count (CBC)

A complete blood count checks your red and white blood cells to look for signs of inflammation and infection. It will also include a platelet count and hemoglobin and hematocrit tests to check for anemia.

Synovial Fluid Exam

Synovial fluid provides cushion and lubrication for joints. It will be extracted from the affected joints and examined for markers of infection and inflammation. For example, the total white blood cell (WBC) count will be elevated in the presence of an infection. The WBC count will also measure the percentage of polymorphonuclear leukocytes count (PMN). In an acutely infected joint, the PMN count will be greater than 95%.

Fluid is also checked for uric acid crystals and will be tested for the presence of bacteria and fungi (and sometimes, viruses).

Molecular Testing

Molecular testing like polymerase chain reaction (PCR) testing can be used to detect organisms in clinical samples. For example, your healthcare provider may order a nucleic acid amplification test (NAAT) to check for gonococci bacteria. Specimens can be collected from the cervix, urethra, throat, or rectum.

Uric Acid Test

A uric acid test measures the amount of uric acid in your blood or urine. It helps diagnose gout.

Risk Factors

Several risk factors can increase your likelihood of having acute arthritis. Some of these risk factors (like age) are out of your control. Others can be controlled with lifestyle modifications.

In some cases, having one form of arthritis increases your likelihood of developing acute arthritis. A common example is rheumatoid arthritis and other disorders causing chronic joint damage. These diseases significantly increase one's risk of infectious arthritis, particularly bacterial arthritis.

Other risk factors include:

• Advanced age (over 60)
• Cancer and chemotherapy
• Chronic illness such as lung or liver disease
• Diabetes
• Having a prosthetic joint
• High-purine diet
• History of joint infection or joint surgery
• Injection drug use
• Immunodeficiencies, including HIV infection
• Immunosuppressive therapies, including corticosteroids
• Gonorrhea
• Lupus
• Sickle cell disease
• Skin infections
• Risk factors associated with sexual disease transmission

Note that these risk factors are strongly associated with immune system functioning and immune suppression and likelihood of exposure to organisms that cause infection. For example, exposure to ticks carrying Borrelia burgdorferi (the cause of Lyme disease) can increase your risk of acute infectious arthritis. If you notice localized redness, swelling, or signs of infection, contact your healthcare provider immediately.

When to See a Healthcare Provider

Joint pain that comes on suddenly isn't always serious but it may be cause for concern. You should see a healthcare professional if you experience symptoms that don't go away, including:

• Pain, swelling, or stiffness
• Joints that are tender, red, or "hot" to the touch
• Mobility problems because of affected joints

Contact your provider if your symptoms last three days or more, or if you experience them several times within the same month.

Treatments

Treatment for sudden onset joint pain will depend on the underlying cause, as well as other factors like your age and overall health. Some conditions may require less intervention than others.

For example, your healthcare provider may treat acute inflammatory arthritis with pain relievers, like nonsteroidal anti-inflammatory medications (NSAIDs) or corticosteroids to reduce symptoms. A referral for physical or occupational therapy also may improve outcomes.

Dietary changes often are part of the treatment plan for gout. Apart from pain relievers, you also may be prescribed Colcrys (colchicine) or medications to help lower uric acid levels, including Zyloprim (allopurinol) and Uloric (febuxostat).

Septic arthritis and infectious arthritis treatment may be more involved due to the cause of the underlying infections. You may need antibiotics like azithromycin and ceftriaxone to kill bacteria, or antifungal medication if a fungal infection is the cause. Other approaches include:

• Drainage of the affected joint using a needle, tube, or surgery (joint aspiration)
• Medications such as NSAIDs to treat other symptoms, including fever and pain
• Splints to relieve joint pain

Other Causes of Sudden Joint Pain

Arthritis is the most common cause for joint pain, but there are other reasons for why all your joints may hurt suddenly. These causes can be related to or include:

• Influenza
• COVID-19 infection
• Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
• Insect stings (as with beekeepers who develop acute inflammatory arthritis)
• Irritable bowel disease (IBD)
• Viruses like Hepatitis B and C
• Polymyalgia rheumatica
  

Summary

Certain conditions can cause you to feel like all of your joints hurt suddenly. These types of arthritis, including acute inflammatory arthritis and gout, cause joint pain and stiffness. Gout may affect just the big toe at first, but it can become extremely painful.

Infectious and septic arthritis are caused by infection, and septic arthritis can develop into a life-threatening condition. It's critical to treat the underlying cause of sudden onset arthritis disorders, which may include pain relief, antibiotics, surgery, and physical therapy.

Even if you’ve been diagnosed with a chronic form of arthritis, you should always discuss any new or sudden onset of joint pain, tenderness, or swelling to rule out acute arthritis. With accurate diagnosis comes proper treatment, and you may feel better and return to regular activity sooner.