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Best At-Home Lyme Disease Tests

IGeneX Inc. offers the easiest-to-use home Lyme disease test

Lyme disease affects thousands of people each year, and if you have a tick bite from your last camping trip, it's best to get tested early for this serious health issue. Thankfully, the best at-home Lyme disease tests can be shipped to your door with a kit to conduct the test from the comfort of your home.

While there are plenty of ways to prevent tick bites, they can still happen to anyone who spends time outside—even the most careful outdoor enthusiasts. We've rounded up the best options to test for Lyme disease at home to help you prepare for the next steps.

Best At-Home Lyme Disease Tests of 2024

Best Overall : IGeneX Inc.


IGeneX Inc logo

IGeneX Inc

Key Specs
  • Price: Under $100
  • Notable Feature: Comprehensive testing
  • Sample Type: Choice of blood or urine 
Why We Chose It

For some people, providing a specific type of sample can be daunting, which is why this test from IGeneX Inc. is a great option. IGeneX Inc. developed an at-home Lyme disease test that can be done through a urine or blood sample.

Pros & Cons
Pros
  • Costs less than $100

  • Choose from using a blood or urine sample

Cons
  • For a blood test, you must visit an iGeneX Lab

  • Results get sent to your doctor, not you

Overview

IGeneX Inc. uses some of the most comprehensive tests in the business to ensure you get accurate results. The company's at-home Lyme disease test looks for more relevant strains of tick-borne pathogens than any other lab.

The test is under $100, and you get to choose your sample: blood or urine. It is important to note that you must visit an IGeneX Lab to give a blood sample. Unlike the other options in this list, this lab sends your results to your doctor first, then you'll be able to view them.

Best for Accuracy : DNA ConneXions


DNA ConneXions

DNA ConneXions

Key Specs
  • Price: $650
  • Notable Feature: Extremely comprehensive testing
  • Sample Type: Urine
Why We Chose It

DNA ConneXions is known in the scientific community for its detailed analysis of lab results. This at-home Lyme disease test is superior to the others because it tests for all 10 vector-borne pathogens, while others only test the most common two or three.

Pros & Cons
Pros
  • Test looks for Borrelia burgdorferi, in addition to 10 other common vector-borne pathogens (most tests look for two or three)

  • Urine sample (no blood)

Cons
  • Cost is high

  • Does not accept insurance

  • No assistance after test results are received

Overview

DNA ConneXions earned our most accurate distinction because of its detailed Lyme disease test, as well as its impressive laboratory with a biosafety level 2 lab with a CLIA (Clinical Laboratory Improvement Amendments) license. This means the company knows its stuff and is able to help people with accurate testing.

After DNA ConneXions receives your urine sample, it will email you your results within two to three weeks. It is unclear how much support the company offers after you receive your results, so it's best to schedule a follow-up appointment with your primary care doctor for further diagnosis and treatment.

This is the most expensive kit on this list, costing about $650 for the full Lyme panel. As of now, it will not work with insurance companies or accept health savings account (HSA) payments. The DNA ConneXions lab, however, is one of the most trusted laboratories worldwide.

Easiest Instructions : Everlywell


Key Specs
  • Price: Around $100 (but works with insurance companies)
  • Notable Feature: Provides health consultant to discuss results
  • Sample Type: Blood
Why We Chose It

Everlywell has a variety of tests, and it has nailed down its testing procedures for a variety of diseases, including Lyme. The company takes the time to ensure that you are completing each step of the test accurately along the way.

Pros & Cons
Pros
  • Results reviewed by an independent, board-certified physician

  • Accepts HSA/FSA payments

Cons
  • Test is around $100 without insurance

Overview

Everlywell’s Lyme disease tests with a blood prick that you then mail in with its easy-to-follow instructions. After the company receives your test, it takes close to six weeks to email your results. A board-certified physician reviews them to ensure their accuracy before they are in your hands.

After you receive your results, Everlywell provides you with a health consultant to discuss findings and next steps. If you test positive or still experiencing symptoms after six weeks, the website recommends that you visit your primary care doctor to ensure that you receive the proper treatment.

Everlywell’s at-home Lyme disease test costs around $100, but the company works with insurance companies. You can also use HSA and flexible spending account (FSA) payments, making the test even easier to access.

Best for Fast Results : LetsGetChecked


LetsGetChecked

LetsGetChecked

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Key Specs
  • Price: Over $100
  • Notable Feature: Results in five days
  • Sample Type: Blood
Why We Chose It

The at-home Lyme disease test from LetsGetChecked is one of the most popular options out there, and the results are fast: The company's website states that you will have your results within five days.

Pros & Cons
Pros
  • Online results within five days

  • LetsGetChecked laboratories are CLIA approved and CAP-accredited

  • Available at CVS.com

  • Accepts HSA/FSA payments

Cons
  • Results are only reviewed by the in-house team

  • Test costs over $100

Overview

After a quick finger prick, you send in a sample of your blood for LetsGetChecked to screen for Borrelia antibodies, which can indicate the presence of Lyme disease.

LetsGetChecked also checks the boxes for being one of the most reliable tests. Its laboratories are CLIA-approved and College of American Pathologists (CAP)-accredited, which are the highest levels of accreditation.

After your results are available, you may receive a call from a member of the LetsGetChecked clinical team to review them, and they will suggest any further steps that you may need to take. The at-home Lyme disease test costs over $100, and while insurance will not cover it, payments can be made via HSA/FSA.

Best for DNA Test : SelfDecode


Self Decode

Self Decode

Key Specs
  • Price: Subscription service that costs about $100
  • Notable Feature: Comprehensive DNA testing
  • Sample Type: Cheek swab 
Why We Chose It

When you take an at-home test through SelfDecode, in addition to checking for Lyme disease, you'll receive an entire mock-up of your DNA. You will know if you ever had Lyme disease in the past, as well as if you are susceptible to PTLDS, a chronic condition triggered by Lyme Disease.

Pros & Cons
Pros
  • Simple cheek swab sample

  • Tests for chronic conditions related to Lyme disease like PTLDS

Cons
  • Results in 6-8 weeks

Overview

SelfDecode tests involve taking a cheek swab, after which the test is mailed back to the company's lab. After six to eight weeks, you will receive your results via email, and you will be contacted by a medical professional to discuss your next steps.

This is a subscription service that costs just under roughly $100 a year, so you will be able to check yourself for Lyme disease regularly. This service is great for those who enjoy the outdoors and are exposed to ticks often.

SelfDecode's test is not covered by insurance, but most primary care physicians will accept these results.

Final Verdict

While there are quite a few at-home Lyme disease tests on the market, our top pick is the one from IGeneX, thanks to its affordability, comprehensiveness, and options for providing a sample. And although it sends results to a doctor instead of straight to you, you may want a doctor to review your results anyway. They can provide you with the best next steps to take.

Compare the Best At-Home Lyme Disease Tests

 Company  Price  Notable Feature Sample Type
IGeneX
Best Overall
Under $100 Comprehensive testing Choice of either blood or urine
DNA ConneXions
Best for Accuracy
$650 Extremely comprehensive testing Urine
EverlyWell
Easiest Instructions
Around $100 (but works with insurance companies) Provides health consultant to discuss results Blood
LetsGetChecked
Best for Fast Results
Over $100 Results in five days Blood
SelfDecode
Best for DNA Test
Subscription service that costs about $100 Comprehensive DNA testing Cheek swab 

Frequently Asked Questions

  • Are At-Home Lyme Disease Tests Accurate?

    Many at-home Lyme disease tests are board-certified, but it is still possible to have a false negative result. The tests mentioned in this article are all certified for the highest level of accuracy available. If you suspect that you have contracted Lyme disease, any of these tests are a helpful first step to learn about a potential infection. However, if you receive a negative result and still have symptoms, it's best to visit your doctor for further testing and diagnosis.

  • What Are the First Signs of Having Lyme Disease?

    Symptoms may vary, but some of the most common first signs of Lyme disease include flu-like symptoms such as fever, chills, and headache. A rash can also occur in 70% to 80% of infections. If left untreated, the symptoms can worsen into facial palsy, dizziness, heart palpitations, and more. Patients can feel sick for months after symptoms first present.

  • How Soon After a Tick Bite Can Lyme Disease Be Detected?

    Lyme disease can be detected a few weeks after a tick bite, once antibodies develop in the body. Most Lyme disease tests detect this disease by its antibodies, so patients are typically tested twice.

  • Can You Test Negative for Lyme Disease and Still Have It?

    Yes. Because Lyme tests look for antibodies, patients may have a false negative test result if tested too early before their body develops antibodies.

Methodology

We reviewed five at-home Lyme disease tests. When evaluating the companies, we looked at several key factors in order to provide you with the best information. Accuracy was extremely important, so we looked at testing centers with the best reviews and certifications. Every test mentioned in this article has been evaluated and awarded for laboratory accuracy when dealing with at-home tests.

Since Lyme disease is so severe and a misdiagnosis can have awful repercussions, we also considered how others reviewed the at-home tests.

at-home lyme disease test

Catherine McQueen / Getty Images

Article Sources
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. Centers for Disease Control and Prevention. Lyme Disease diagnosis and testing.