Infectious Diseases Coronavirus (COVID-19) What Should You Do If You Feel Sick but Keep Testing Negative for COVID? By Carla Delgado Updated on March 25, 2024 Medically reviewed by Sameena Zahoor, MD Fact checked by Nick Blackmer Print Verywell / Amelia Manley Key Takeaways COVID-19 shares similar symptoms with other respiratory infections.If you're symptomatic but test negative, it's important to take appropriate precautions.Per the CDC, you can leave your home after being fever-free for 24 hours without the help of medications AND if symptoms are improving.Take additional precautions for five days following isolation, such as wearing a well-fitting mask, keeping a distance from others, and washing your hands often. It’s always concerning to feel unwell because symptoms like coughing or a runny nose can mean anything—seasonal allergies, the flu, or even COVID-19. Amesh Adalja, MD, an infectious disease expert and senior scholar at the Johns Hopkins Center for Health Security, told Verywell that it’s hard to tell respiratory infections apart without diagnostic testing because many symptoms overlap. A negative result from a COVID-19 rapid test is usually enough to ease worries, but one test isn’t enough to rule it out. One negative result could mean that you don’t have a contagious amount of the virus at the time of testing, even if you do have COVID-19 already, Adalja said. If you have COVID-like symptoms but test negative, it's important to take precautions. According to the Centers for Disease Control and Prevention (CDC), if you test positive for COVID or have symptoms of a respiratory viral infection: Isolate at home until you've been fever-free for 24 hours (without the help of medication) AND your symptoms are mild and improving.Take additional precautions for five days following isolation, such as wearing a well-fitting mask, keeping a distance from others, and washing your hands often. Will Omicron Show Up On Rapid COVID Tests? Irfan Hafiz, MD, an infectious diseases expert at Northwestern Medicine, told Verywell that community prevalence could help determine whether your symptoms are that of a seasonal problem. The CDC’s flu activity map, for example, can tell you if your region has had a high rate of flu cases in the last week. If you’re still unsure whether you have COVID, you can take over-the-counter medications such as ibuprofen or acetaminophen for symptom relief, Hafiz said. In the meantime, it’s best to stay home until you've been fever-free for 24 hours without the help of medications AND if your symptoms are improving. You No Longer Need a Positive COVID Test to Receive Paxlovid There is currently no preventive medication for COVID-19. However, you can help reduce the risk of severe illness by staying up to date with COVID-19 vaccines. At times of high community prevalence of COVID-19, Hafiz said it’s best to avoid overcrowded situations and wear a mask in public. What This Means For You If you feel sick but you test negative for COVID-19, it’s recommended that you stay home until you've been fever-free for 24 hours without the help of medications AND if symptoms are improving. You should also take additional precautions for five days following isolation. This includes wearing a well-fitting mask, keeping a distance from others, and washing your hands often. The information in this article is current as of the date listed, which means newer information may be available when you read this. For the most recent updates on COVID-19, visit our coronavirus news page. 2 Sources Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Centers for Disease Control and Prevention. Respiratory Virus Guidance Update FAQs. Centers for Disease Control and Prevention. Stay up to date with COVID-19 vaccines. By Carla Delgado Delgado is a health and culture writer specializing in health, science, and environmental sustainability. See Our Editorial Process Meet Our Medical Expert Board Share Feedback Was this page helpful? Thanks for your feedback! What is your feedback? Other Helpful Report an Error Submit